This chapter introduces the PROSE (Persona, Rubric, Objective, Steps, and Example) prompting model as a systematic approach for embedding generative artificial intelligence (AI) into instructional practice. Grounded in the principles of constructive alignment, this chapter demonstrates the value of prompts being intentionally crafted to align learning objectives, teaching activities, and assessment tasks with AI-mediated interactions. We begin by outlining the theoretical foundations of constructive alignment and situate the PROSE model’s five components. We then offer a step-by-step guide for educators to develop generative AI prompts that target learning outcomes. These guidelines are illustrated through example use cases, along with reflections from instructors (the authors) and feedback on the model from their students, highlighting how prompt design decisions shape engagement, feedback quality, and alignment with intended outcomes. This chapter provides the conceptual foundation, practical examples, and actionable strategies for educators to integrate generative AI into outcome-driven teaching and learning.