An overview of the need for change in higher education programs of teacher preparation is presented. The authors summarize what needs to change based on the research of educational leaders, the Partnership for 21st Century Skills, and leading educational organizations. They address what it means to be highly qualified, a model for teacher preparation, and needed policy changes in the context of 21st century learning. A hypothetical case study of two preservice teachers closes the chapter with a vision of hope for the future.